DrugRepoDb contains a standard set of drug repositioning successes and failures that can be used to fairly and reproducibly benchmark computational repositioning methods. DrugRepoDb data was extracted from DrugCentral and ClinicalTrials.gov.

The DrugRepoDb website has several functionalities, which can be accessed from the navigation bar:

  • Drug-centric searching
  • Disease-centric searching
  • Full DrugRepoDB download

You can explore the types and characteristics of data in DrugRepoDb in the plot below.

DrugRepoDb contains information for 2459 currently approved drugs (as curated by DrugCentral). To search DrugRepoDb for a specific drug, select a drug and the current statuses you'd like to display. Drugs are listed with their DrugCentral and DrugBank IDs, for easier integration into your existing pipelines. Search results can be downloaded as a tab-separated values file using the download button below the table of drug indications.

Download the current search results

DrugRepoDb contains information for 1538 diseases (indications), all mapped to UMLS terms for easier integration into your existing pipelines. To search for a specific disease, select a disease and the current statuses you'd like to display. Search results can be downloaded as a tab-separated values file using the download button below the table of drug indications.

Download the current search results

The full DrugRepoDb database is available for download using the button below. Please note that the data is presented as-is, and not all entries have been validated before publication.

Download the full DrugRepoDB Dataset

To acknowledge use of the DrugRepoDb resource, please cite the following paper:

Brown AS and Patel CJ. repoDB: A New Standard for Drug Repositioning Validation. Scientific Data. 170029 (2017).

DrugRepoDb was built using the September 02, 2026 release of DrugCentral, the live version, accessed in September 2026, of the AACT database, and the 2020AA Release of the Unified Medical Language System. Metformin and recycling symbol used under CC0 license from Wikimedia Commons. Database symbol by Designmodo, used under a CC3.0 license.

By using the DrugRepoDb database, users agree to cite our work, as well as AACT, DrugCentral, and UMLS for their role in data curation. This data is available under a Creative Commons Attribution 4.0 International License.

As DrugRepoDb is improved and augmented with new data, we will track any substantial changes made to DrugRepoDb here:

  • v1.0 (March 14, 2017) - Initial release
  • v1.1 (June 26, 2017) - Fixed a bug in the ClinicalTrials.gov parser that created multiple DrugBank Identifiers for a single drug (many thanks to Cristina Leal for spotting the error).
  • v1.2 (July 28, 2017) - Version History tab was added to address discrepancies introduced in totals for Terminated Withdrawn, and Suspended drug-disease pairs versus published values due to bugfix in v1.1 (many thanks to Beste Turanli for spotting the discrepancy).
  • v2.0 (June 12, 2020) - Updated by Jeremy Yang at the University of New Mexico (UNM), with latest versions of DrugCentral, AACT and UMLS.
  • v2.1 (June 15, 2023) - Updated by Jeremy Yang (UNM), with latest versions of DrugCentral (2023-05-10), AACT (2023-06-14) and UMLS (2023AA).
  • v2.2 (September 10, 2026) - Updated by Jeremy Yang (UNM), with latest versions of DrugCentral (2026-09-02), AACT (2026-09-02) and UMLS (2026AA).

DrugRepoDb is intended for educational and scientific research purposes only. This work is licensed under a Creative Commons Attribution 4.0 International License. DrugRepoDb was originally developed by AS Brown and CJ Patel, at the Harvard SoM Patel Group . In 2020, DrugRepoDb was updated by Jeremy Yang from the University of New Mexico (UNM), SoM, DoIM, Translational Informatics Division in cooperation with the original developers, with new versions of DrugCentral, AACT, and UMLS. The 2023 and 2026 updates were also released by UNM.